The Effect of Oxygen on Peripheral Airways

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Abstract
In 10 normal young subjects, 4 alveolar O2-concentration levels ranging from about 7-95% were obtained by breathing different concentrations of O2 in N2 at a constant alveolar CO2-concentration of about 5%. Maximum expiratory flows at 60% TLC [total lung capacity] were measured at each level and corrected for the influence of the expired gas density on flow. The corrected maximum flows were not significantly different, which is taken as evidence of no effect of O2 on tone of peripheral bronchi.