The effect of antenatal dexamethasone administration on glomerular filtration rate and renal sodium excretion in premature infants
- 1 January 1987
- journal article
- Published by Springer Nature in Pediatric Nephrology
- Vol. 1 (2) , 131-135
- https://doi.org/10.1007/bf00849282
Abstract
Creatinine clearance (Ccr) and renal sodium (Na+) excretion were measured in 10 premature infants (gestational age + excretion were significantly lower (P+∶Na+ ratio significantly higher (Pcr did not differ between groups. In study 2, Ccr in group D had increased compared both with values obtained in the same babies in study 1 (PP+ excretion and urinary K+∶Na+ ratio were no longer found. We conclude that exogenous glucocorticoids accelerate maturation of renal function in immature human infants, probably by inducing tubular Na+. K+-ATPase activity. Our findings support the view that endogenous glucocorticoid hormones may play an important part in the normal maturation process.Keywords
This publication has 31 references indexed in Scilit:
- SODIUM EXCRETION IN RELATION TO SODIUM INTAKE AND ALDOSTERONE EXCRETION IN NEWBORN PRE-TERM AND FULL-TERM INFANTSActa Paediatrica, 2008
- Sodium homeostasis in term and preterm neonates. II. Gastrointestinal aspects.Archives of Disease in Childhood, 1983
- POSTNATAL DEVELOPMENT OF RENAL FUNCTION IN PRE‐TERM AND FULL‐TERM INFANTSActa Paediatrica, 1981
- Postnatal development of renal sodium handling in premature infantsThe Journal of Pediatrics, 1979
- Prenatal administration of betamethasone for prevention of respiratory distress syndromeThe Journal of Pediatrics, 1979
- ALDOSTERONE AND SODIUM HOMEOSTASIS IN PRETERM INFANTSActa Paediatrica, 1977
- RENAL FUNCTION AS A MARKER OF HUMAN FETAL MATURATIONActa Paediatrica, 1976
- RENAL CONTROL OF SODIUM and FLUID BALANCE IN NEWBORN INFANTS DURING INTRAVENOUS MAINTENANCE THERAPYActa Paediatrica, 1975
- Urine and stool collection for metabolic studies in the newborn.Archives of Disease in Childhood, 1974
- The Relationship Between Electrolyte and Acid-Base Balance in the Premature Infant during Early Postnatal LifeNeonatology, 1971