Intratumor treatment off C3H mouse mammary carcinoma with 5-fluorouracil adsorbed on activated charcoal particles
- 1 June 1992
- journal article
- research article
- Published by Wolters Kluwer Health in Anti-Cancer Drugs
- Vol. 3 (3) , 261-266
- https://doi.org/10.1097/00001813-199206000-00009
Abstract
A dosage form comprising 5-fluorouracil (5-FU, 25 mg/ml) adsorbed on a suspension of micronized charcoal (100 mg/ml) 2–5 μm in diameter, adsorbing 5-FU in aqueous solution was studied for intratumor treatment of mammary carcinoma in animal experiments. An In vitro desorption method is described to determine the amount of 5-FU adsorbed on activated charcoal particles which would be released once the drug concentration decreased around the charcoal. In vivo results indicate that an intratumor Injection of 5-FU adsorbed on activated charcoal particles is a highly effective method for achieving tumor regression without increasing toxicity.Keywords
This publication has 0 references indexed in Scilit: