Stability of parenteral Solutions of Sodium Cephalothin, Cephaloridine, Potassium Penicillin G (Buffered) and Vancomycin Hydrochloride
- 1 October 1971
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Health-System Pharmacy
- Vol. 28 (10) , 760-763
- https://doi.org/10.1093/ajhp/28.10.760
Abstract
The clinical convenience of preparing in advance antibiotic solutions for intravenous administration has necessitated the availability of solution stability data. Refrigerated and room temperature solution stability profiles for sodium cephalothin, cephaloridine, potassiiun penicillin G (buffered) and vancomycin hydrochloride in 5% dextrose, 0.9% saline and water for injection are reported. The need to obtain precise data by methods such as those described in the Code of Federal Regulations is discussed. The necessity of evaluating activities of antibiotics in solution in terms of biologically active degradation products, integrity of parent compound, pH and physical characteristics is also discussed.Keywords
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