Acinar-duct transport sites for Na+ and K+ in dog submaxillary salivary gland

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Abstract
The submaxillary gland of the dog was employed to determine the relative roles of the acini and ducts in the net transport of Na+ and K+ into saliva. Three methods were used: stop flow, with periods of 2- and 8-min occlusion; retrograde injection of mercuric chloride (0.05% concentration and 0.2 cc in vol) into each submaxillary duct system, an adaptation of the method of Nicholson; time zero studies, a collection of salivary samples from a gland which had rested for at least 30 min before stimulation. The ducts were found to resorb Na+ and water at all flow rates and to secrete K+ into the saliva. K+ was found to be stored in the gland. There was evidence that Na+ and K+ were either filtered from the plasma or secreted by the acini into the lumen at concentrations similar to plasma levels.

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