Methodological Differences in Clinical Trials Evaluating Nonpharmacological and Pharmacological Treatments of Hip and Knee Osteoarthritis
Open Access
- 27 August 2003
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 290 (8) , 1062-1070
- https://doi.org/10.1001/jama.290.8.1062
Abstract
Randomized controlled trials (RCTs) are widely accepted as the most reliable method of determining the effectiveness of specific therapies.1 The design, conduct, and analysis of clinical trials aim at providing valid results, which implies that the treatment effect reported represents its true direction and magnitude2 and that the trial minimizes bias, which can distort results.3,4Keywords
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