A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats
Open Access
- 2 June 2010
- journal article
- Published by Springer Nature in Virology Journal
- Vol. 7 (1) , 114
- https://doi.org/10.1186/1743-422x-7-114
Abstract
Respiratory syncytial virus (RSV) is a primary cause of serious lower respiratory tract illness for which there is still no safe and effective vaccine available. Using reverse genetics, recombinant (r)RSV and an rRSV lacking the G gene (ΔG) were constructed based on a clinical RSV isolate (strain 98-25147-X).Keywords
This publication has 33 references indexed in Scilit:
- Respiratory Syncytial Virus Vaccine DevelopmentClinics In Laboratory Medicine, 2009
- Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus diseaseNature Medicine, 2008
- Overcoming T-Cell-Mediated Immunopathology to Achieve Safe Respiratory Syncytial Virus VaccinationFuture Virology, 2008
- The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccinesVaccine, 2007
- New Generation Live Vaccines against Human Respiratory Syncytial Virus Designed by Reverse GeneticsProceedings of the American Thoracic Society, 2005
- Recombinant Human Metapneumovirus Lacking the Small Hydrophobic SH and/or Attachment G Glycoprotein: Deletion of G Yields a Promising Vaccine CandidateJournal of Virology, 2004
- Characterization of Recombinant Respiratory Syncytial Viruses with the Region Responsible for Type 2 T-Cell Responses and Pulmonary Eosinophilia Deleted from the Attachment (G) ProteinJournal of Virology, 2004
- Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approachesThe Pediatric Infectious Disease Journal, 2003
- Mucosal Immunization with Live Recombinant Bovine Respiratory Syncytial Virus (BRSV) and Recombinant BRSV Lacking the Envelope Glycoprotein G Protects against Challenge with Wild-Type BRSVJournal of Virology, 2002
- Respiratory syncytial virus infections in childrenSeminars in Respiratory Infections, 2002