Role of activated nuclear factor‐κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
- 2 April 2007
- journal article
- review article
- Published by Wiley in Head & Neck
- Vol. 29 (10) , 959-971
- https://doi.org/10.1002/hed.20615
Abstract
Nuclear factor-kappaB (NF-kappaB), a transcription factor known to modulate expression of factors involved in inflammation, immunity, proliferation, and apoptosis, is constitutively activated and plays a role in pathogenesis and therapeutic resistance in head and neck squamous cell carcinoma (HNSCC). Understanding the molecular alterations leading to aberrant NF-kappaB activation in HNSCC may direct investigators to novel therapeutic targets. Results of laboratory and clinical studies are reviewed. The structure, function, and activation of NF-kappaB, products of NF-kappaB target genes and their role in HNSCC oncogenesis, and current NF-kappaB modulating interventions are described. Aberrant NF-kappaB activation contributes to the expression of oncogenes and the malignant phenotype observed in HNSCC. NF-kappaB, along with providing a link between cancer and inflammation, may serve as an appropriate therapeutic target to inhibit tumor growth and sensitize cancer cells to established cytotoxic anticancer therapies.Keywords
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