Further studies on the reaction of disulphides with silver nitrate

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Abstract
The kinetics of the reaction of silver nitrate with 8 disulfides were studied. It was found that, under given conditions, the reaction is first-order in respect of each reactant. Under these conditions the reactivity of the different disulfides may be compared. Possible reasons for the observed differences in reactivity are discussed. It is suggested that the high reactivity of homocystine, and possibly of oxidized glutathione, is due to interaction between the amino groups and the S atoms. Evidence for this is discussed. The conditions for estimating the 8 disulfides are given, a potentiometric titration with mercuric chloride being used. The results are compared with those obtained by other methods.