CORONARY DILATORS AND ANGINA

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Abstract
The physiology of the coronary circulation and the problems of human coronary disease have been under investigation for over 20 years in this department. It is our purpose to reexamine certain aspects that form the basis for the clinical use of coronary vasodilator drugs and to summarize our results with several of the preparations in current use. Drugs that dilate the coronary vessels are useful. The usefulness of a drug, however, does not lie simply in the demonstration of such dilatation. Of equal importance is the necessity of ascertaining that such drugs do not divert blood from the coronary circuit by a disproportionate dilator action on one or more of the other systemic circuits. Under such circumstances, even a coronary dilator drug may leave the coronary flow unchanged or actually decreased. Secondly, it must always be established that drugs that increase coronary flow do not at the same time increase

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