Pharmacological enhancement of fibrinolytic activity and125I-fibrinogen survival
- 1 December 1970
- journal article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 23 (9) , 797-800
- https://doi.org/10.1136/jcp.23.9.797
Abstract
Studies with (125)I-fibrinogen after the administration of phenformin plus ethyloestrenol in five subjects showed no evidence of enhanced catabolism of fibrinogen despite a fall in plasma fibrinogen concentration and shortened clot lysis time. It seems probable that the fall in plasma fibrinogen concentration after the administration of these drugs is related to diminished hepatic synthesis of fibrinogen and is independent of the induction of plasminogen activator release.Keywords
This publication has 7 references indexed in Scilit:
- In vivo behaviour of frozen and freeze-dried fibrinogen and of that prepared from out-dated bloodBiochimica et Biophysica Acta (BBA) - Protein Structure, 1969
- FIBRINOLYTIC AND DEFIBRINATING EFFECT OF PHENFORMIN PLUS ETHYLŒSTRENOL IN VIVOThe Lancet, 1969
- Fibrinogen Catabolism in Microangiopathic Haemolytic AnaemiaBritish Journal of Haematology, 1968
- Metabolism of 125-I-fibrinogen in normal monkeys and in those with pharmacologically induced plasminogen activator release.1967
- FIBRINOLYTIC TREATMENT OF RHEUMATOID ARTHRITIS WITH PHENFORMIN PLUS ETHYLŒSTRENOLThe Lancet, 1966
- Studies of the metabolism and distribution of fibrinogen in healthy men with autologous 125-I-labeled fibrinogen.Journal of Clinical Investigation, 1966
- Measurement of spontaneous fibrinolytic activityJournal of Clinical Pathology, 1964