Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
Open Access
- 21 October 2008
- journal article
- Published by Springer Nature in Molecular Neurodegeneration
- Vol. 3 (1) , 16
- https://doi.org/10.1186/1750-1326-3-16
Abstract
The multifunctional protein vitronectin is present within the deposits associated with Alzheimer disease (AD), age-related macular degeneration (AMD), atherosclerosis, systemic amyloidoses, and glomerulonephritis. The extent to which vitronectin contributes to amyloid formation within these plaques, which contain misfolded, amyloidogenic proteins, and the role of vitronectin in the pathophysiology of the aforementioned diseases is currently unknown. The investigation of vitronectin aggregation is significant since the formation of oligomeric and fibrillar structures are common features of amyloid proteins.Keywords
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