Studies in detoxication. 59. The metabolism of alkylbenzenes. The biological reduction of ketones derived from alkylbenzenes

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Abstract
Ethyl phenyl, phenyl n-propyl, benzyl methyl, benzyl ethyl and methyl phenethyl ketones are partly reduced in the rabbit to secondary car-binols and the latter are excreted in conjugation with glucuronic acid. The glucuronides were isolated and characterized as triacetyl methyl esters. Ethyl phenyl and phenyl n-propyl ketones were apparently reduced to the corresponding l- carbinols and benzyl methyl ketone to the d - carbinol. These carbinols are configuratively related to l-methylphenylcarbinol. dl-Benzylmethylcarbinol gives rise in rabbits to the glucuronides of both isomers of the carbinol.