FUNGUS-INHIBITIVE PROPERTIES OF BROMOACETAMIDES

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Abstract
A group of new compounds, 26 N-alkyl alpha-bromoacetamides and 10 N-aryl alpha-haloamides have been assayed as fungus inhibitors. A high order of toxicity is indicated for certain bromoacetamides, notably the N-phenyl and the N-alkyls in which the substituent contains 4-10 carbon atoms. The mono-N-substituted compounds are more active than the di-substituted; the primary alkyls are more active than the secondary; and the normal chains are more potent than the branched ones. Among the aromatic compounds, none exceeded the simple N-phenyl derivative, bromoacetanilide, in activity. On the basis of limited observations it is predicted that the chlorine analogs of these compounds are much less active, and that polyhalogenation of the carbon will not augment the fungistatic powers. The dosage response data indicate that the action of these toxic compounds is not attributable simply to the activation of bromine or to any other single mechanism.
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