Effect of generalized graft-versus-host-reaction on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 92 (3) , 255-265
- https://doi.org/10.1007/bf00461648
Abstract
The investigations of 400 adult hybrids from A/Jax fem. BALB/c male were aimed at answering the following questions: What is the influence of a generalized graft-versus-host-reaction (GVHR) on the induction and growth of benzpyrene-induced sarcoma? What is the behavior of B- and T-lymphocytes during GVHR, and during induction and growth of benzpyrene-induced sarcoma? Which are the deductions to be drawn with regard to the effect of B- and T-lymphocytes during tumorigenesis and tumor growth? The number of tumors was significantly greater in the GVHR animals (74.5%) than in the controls (49.5%). A significant decrease of T-lymphocytes and increase of B-lymphocytes during GVHR were found in the peripheral blood. The examination of the tumor marginal zone showed a marked decrease of the total round cell count and the T cells, while the count of B-lymphocytes remained uninfluenced. These results are discussed and compared with results of other authors.Keywords
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