Determination of Red Blood Cell Life Span

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Abstract
ALL VARIATIONS in the total volume of circulating red blood cells (RBC) can be thought of as resulting from an alteration in either the rate of production of cells or the cell life span. Methods for the determination of the rate of cell production have been described elsewhere.1 This review will be concerned with the measurement of the red cell life span in man. Methods There are two classes of direct methods for measurement of red cell life span, cohort and random labeling. The cohort methods require the biosynthetic introduction of a label into a group of newly synthesized cells and the quantitative determination of the persistence of the label in the circulating erythrocytes. The precursors used are glycine C14,2 glycine N15,3 glycine H3,4 and a radioactive iron (Fe59) compound.5 (A cohort of labeled cells has been prepared in the dog

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