Zur Bedeutung von Lysolecithin für die Immuncytolyse von Mastzellen

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Abstract
In an immune system consisting of rat peritoneal mast cells and rabbit anti-rat-gamma-globulin, cytolysis occurs in the presence of an appropriate fresh serum. If in addition to the above reactants antigen (rat-gamma-globulin) is present, the antigen-antibody reaction takes palce only in the surrounding medium; under these conditions, immune cytolysis does not occur. Pharmacological evaluation of lysolecithin revealed that, in the presence of human analbumin serum, low concentrations (1 [mu]g/ml) of this agent produce cytolysis; in the presence of normal human serum, however, no such effects could be observed. Against this, only slight differences were observed between normal and analbuminserum in immune cytolysis. These results as well as those obtained in in vivo experiments do not support the hypothesis that lysolecithin has a systemic effect in these reactions; on the other hand, a local effect of lysolecithin limited to the area of the interaction of antigen and antibody cannot be ruled out.