Evidence that ‘Inactive’ Renin is Produced outside the Kidney of the Rat

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Abstract
Inactive renin, which can be converted into an active form by acidification to pH 3.3, represents 4-63% of the total renin in rat peripheral plasma. No inactive component could be found in the blood-free venous effluent of the perfused rat kidney before and after stimulation with isoprenaline. This suggests a possible extrarenal source for inactive renin and may explain the presence of this component in anephric patients.