Renal Excretion of Digitoxin in Man Following Oral Administration.

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Abstract
The daily excretion of digitoxin in the urine of 4 males and 1 female adult after ingestion of 1.2 mg. of digitoxin within 6 hours was detd. by means of the embryonic duck heart assay. Urine was boiled to 25% of original volume, dried upon infusorial earth at 80[degree] C in vacuo, and the dry powder extracted with chloroform and ethanol. Solvents were removed from the extract in vacuo and the residue dissolved in Tyrode''s soln. which was assayed by comparison with similarly treated normal urine to which known amts. of digitoxin had been added. Excretion varied as much as 300% from subject to subject, averaging approx. 14% of the administered dose in the first 72 hours after ingestion.

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