Rate of decay and distribution volume of MB isoenzyme of creatine kinase, intravenously injected into the baboon.
Open Access
- 1 July 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 22 (7) , 1095-1097
- https://doi.org/10.1093/clinchem/22.7.1095
Abstract
We determined the decay constant and distribution space of the MB isoenzyme of creatine kinase after intravenous injection of 440 to 720 U, in a group of seven adult baboons. The rate of decay of the isoenzyme was monoexponential, with a mean decay constant of 0.00175 min-1 (SD, 0.00019). The mean distribution volume obtained by extrapolation of the monoexponential curve to zero time was 5.22% (SD, 1.06) of body weight. We have determined these parameters with the purpose of using this isoenzyme in the baboon as an experimental model for measuring myocardial infarct size.This publication has 0 references indexed in Scilit: