Enhancement of Human Guanylate Cyclase Activity by Chemical Carcinogens
- 1 July 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 155 (3) , 301-304
- https://doi.org/10.3181/00379727-155-39794
Abstract
The effect of 3 carcinogens, streptozotocin, methylnitrosourea and hydrazine, on guanylate cyclase activity in a variety of human tissues obtained from autopsy specimens 1-12 h after death was examined. Streptozotocin and methylnitrosourea produced 2- to 6-fold increases in guanylate cyclase activity in lung, liver, colon, kidney, stomach, duodenum, heart and pancreas. Hydrazine increased guanylate cyclase activity 21-fold in lung, 52-fold in pancreas, 35-fold in kidney, 24-fold in heart and 9-fold in liver. The data in this report may explain the tumor inducing capacity of these 3 carcinogens.This publication has 6 references indexed in Scilit:
- ACTIVATION OF GUANYLATE CYCLASE BY STREPTOZOTOCIN AND 1-METHYL-1-NITROSOUREA1977
- Guanylate cyclase activity in fetal, neonatal and adult rat heartJournal of Molecular and Cellular Cardiology, 1976
- Calcium-Independent Modulation of Cyclic GMP and Activation of Guanylate Cyclase by NitrosaminesScience, 1976
- The content and metabolism of cyclic adenosine 3', 5'-monophosphate and cyclic guanosine 3', 5'-monophosphate in adenocarcinoma of the human colon.Journal of Clinical Investigation, 1976
- Pancreatic Islet Cell CarcinomaAnnals of Internal Medicine, 1973
- A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counterAnalytical Biochemistry, 1960