Specific Inhibitors of Dipeptidyl Peptidase IV Suppress mRNA Expression of DP IV/CD26 and Cytokines

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Abstract
The dipeptidylpeptidase IV is an activation marker on T B and NK cells Specific inhibitors of DP IV suppress DNA synthesis, as well as cytokine protein production Here, we describe for the first time the quantitative changes of mRNA expression of IFN-γ, IL-2, IL-12 and DP IV after inhibition of DP IV Due to the stimulation of human peripheral blood mononuclear cells (PBMC) with pokeweedmitogen (PWM) both cytokine as well as DP IV mRNA expression is increased significantly Treatmentwith DP IV inhibitor suppresses dose-dependentlythese changes Importantly, mRNA expression of DP IV itself was inhibited The presented data are fully compatible with our hypothesis that inhibition of DP IV leads to cell cycle arrest in late Gl due to enhanced IGI-β1 expression