Methylation of Inorganic and Organic Selenium by the Bacterial Thiopurine Methyltransferase
Open Access
- 1 June 2002
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 184 (11) , 3146-3149
- https://doi.org/10.1128/jb.184.11.3146-3149.2002
Abstract
Escherichia coli cells expressing the tpm gene encoding the bacterial thiopurine methyltransferase (bTPMT) are shown to methylate selenite and (methyl)selenocysteine into dimethylselenide (DMSe) and dimethyldiselenide (DMDSe). E. coli cells expressing tpm from a gene library cosmid clone (harboring a Pseudomonas syringae insert of about 20 kb) also methylated selenate into DMSe and DMDSe. bTPMT is the first methyltransferase shown to be involved in the methylation of these selenium derivatives.Keywords
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