Trojan-Horse Lymphocytes

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Abstract
This week's issue of the Journal brings news of two infants in whom fatal graft-versus-host disease developed after intrauterine and exchange transfusions for hemolytic disease of the newborn. The Journal of December 6, 1973, published as its weekly clinicopathological exercise the case of a 27-year-old man who had the nephrotic syndrome with Hodgkin's disease.1 Although the diseases affecting the infants and the man hardly seem related, I shall attempt to link them by a common mechanism.Ordinarily, transplanted foreign cells or tissues are rejected by an immune response engendered in the recipient by antigens of the graft. However, if the . . .

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