Statistical Issues in Interpretation of Chronic Bioassay Tests for Carcinogenicity
- 1 April 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 62 (4) , 957-974
- https://doi.org/10.1093/jnci/62.4.957
Abstract
The interpretation of chronic bioassay tests for carcinogenicity requires that the data be appropriately recorded. A “case history” for each animal links the pathology data for each organ of each animal to the length of its life. This information can be used in interpretation of the tumor incidence in light of the survival information. The role of historical controls was discussed, and the use of significance tests in a multidisciplinary approach to the assessment of the pattern of tumor response was suggested. Multiple comparison methods valid for the interpretation of continuous (or measurement) data do not apply to the discrete data analyses used in these studies. The ideas and methods of these studies were appliedd to an animal study of chloroform.Keywords
This publication has 5 references indexed in Scilit:
- The Use of a Correlated Binomial Model for the Analysis of Certain Toxicological ExperimentsBiometrics, 1978
- Use of statistics when examining lifetime studies in rodents to detect carcinogenicityJournal of Toxicology and Environmental Health, 1977
- Trend and homogeneity analyses of proportions and life table dataComputers and Biomedical Research, 1977
- On distribution-free tests for equality of survival distributionsBiometrika, 1977
- FALSE-POSITIVE AND FALSE-NEGATIVE RATES FOR CARCINOGENICITY SCREENS1977