Treatment of arrhythmias with tolamidol

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Abstract
Tolamidol (UK‐6558‐01), a beta adrenergic blocking agent with less myocardial depressant effect than propranolol, was given intrauenously to 30 patientl with cardiac arrhythmias. It abolished or greatly reduced digitalis‐induced arrhythmias in 5 of 5 patients, the arrhythmias being frequent premature ventricular beats, ventricular tachycardia, frequent premature atrial beats, and paroxysmal atrial tachycardia with 2:1 atrioventricular block. Paroxysmal atrial tachycardia, atrial fibrillation and a rapid ventricular rate, paroxysmal atrial flutter, and frequent premature atrial beats, were abolished or improved in many instances. Tolamidol was useful in treating digitalis‐induced arrhythmias and supraventriculiar arrhythmias, but was not very effective in treating frequent premature ventricular beats, not digitalis induced.

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