RELATION OF GLOMERULAR FILTRATION RATE AND SODIUM TUBULAR REJECTION FRACTION TO RENAL SODIUM EXCRETION

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Abstract
The mechanism of Na excretion was studied in 60 subjects. The group was selected to provide a representative cross-section of filtration rates. Dietary Na intake was sufficiently varied to insure a wide range of Na excretion rates. The objective of the study was not to determine why one subject excreted more Na than another, but to ascertain whether or not the observed differences in output could primarily be explained by differences in glomerular filtration rate or by variations in tubular reabsorption. A high correlation was found between the rate of Na excretion and the magnitude of the tubular rejection fraction. No significant relation to filtration rate was established. Ten- to 50-fold variations in Na output were observed at nearly identical rates of, filtration. No evidence was found that the relationships observed had been significantly influenced by the use of mannitol in the clearance measurements.
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