The stoichiometry of the exchange catalysed by the mitochondrial calcium/sodium antiporter
- 1 July 1985
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 229 (1) , 161-166
- https://doi.org/10.1042/bj2290161
Abstract
Rat heart mitochondria respiring on succinate in the presence of Ru red (to inhibit uptake on the Ca2+ uniporter) released Ca2+ on the Ca/Na antiporter until a steady state was reached. Addition of the ionophore A23187 (which catalyzes Ca2+/2H+ exchange) did not perturb this steady state. Thermodynamic analysis showed that if a Ca2+/nNa+ exchange with any value of n was at equilibrium, addition of A23187 would cause an obvious change in extramitochondrial free [Ca2+]. The endogenous Ca/Na antiporter of mitochondria catalyses electroneutral Ca2+/2Na+ exchange.This publication has 31 references indexed in Scilit:
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