DCP-1, a Drosophila Cell Death Protease Essential for Development
- 24 January 1997
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 275 (5299) , 536-540
- https://doi.org/10.1126/science.275.5299.536
Abstract
Apoptosis, a form of cellular suicide, involves the activation of CED-3-related cysteine proteases (caspases). The regulation of caspases by apoptotic signals and the precise mechanism by which they kill the cell remain unknown. In Drosophila , different death-inducing stimuli induce the expression of the apoptotic activator reaper . Cell killing by reaper and two genetically linked apoptotic activators, hid and grim , requires caspase activity. A Drosophila caspase, named Drosophila caspase-1 (DCP-1), was identified and found to be structurally and biochemically similar to Caenorhabditis elegans CED-3. Loss of zygotic DCP-1 function in Drosophila caused larval lethality and melanotic tumors, showing that this gene is essential for normal development.Keywords
This publication has 41 references indexed in Scilit:
- Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell DeathCell, 1996
- Programmed cell death in invertebratesCurrent Opinion in Genetics & Development, 1996
- Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32Journal of Biological Chemistry, 1996
- Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 proteinNature, 1995
- Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting EnzymeScience, 1995
- Apoptosis in the Pathogenesis and Treatment of DiseaseScience, 1995
- Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.Genes & Development, 1994
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzymeCell, 1993
- A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytesNature, 1992
- Mechanisms and Functions of Cell DeathAnnual Review of Cell Biology, 1991