Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
- 14 March 2004
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 7 (4) , 335-336
- https://doi.org/10.1038/nn1214
Abstract
Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.Keywords
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