EFFECTS OF ULTRAVIOLET-IRRADIATION ON EPIDERMAL LANGERHANS CELLS IN GUINEA-PIGS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 51  (1) , 143-151
Abstract
There is good evidence to suggest that UV irradiation (UVB) of the skin causes a reduction in the numbers of normal epidermal Langerhans cells (LC) in man and mouse. Little information is available on the effects of UV radiation on LC in guinea-pig skin. Different dosages of UVB and UVC were applied to the ear skin of guinea-pigs. UVC irradiations were more effective than UVB in causing depletions of ATPase-positive epidermal LC. Highly significant depletions, lasting 6 days after irradiation, were produced with little evidence of significant inflammatory reactions occurring in the epidermis.