RELATIONSHIP BETWEEN CYP1A ENZYME ACTIVITIES AND PROTEIN LEVELS IN RATS TREATED WITH 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN
- 1 March 1996
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 47 (4) , 379-394
- https://doi.org/10.1080/009841096161717
Abstract
Induction of CYP1A1 is one of the best characterized responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). EROD activity has been used as an enzymatic marker for CYP1A1 following TCDD treatm ent. Enzymatic markers for the induction of CYP1A2 by TCDD are not as well characterized. The present study examines the relationship between CYP1A1 and CYP1A2 protein and the corresponding enzymatic markers. Induction of hepatic ethoxyresorufin O-deethylase (EROD) activity and methoxyresorufin O -demethylase (MEROD) and acetanilide 4-hydroxylase (ACOH) activity (both markers for CYP1A2)Keywords
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