EFFECT OF 2-THIOURACIL ON THE HISTOLOGY OF THE NORMAL HUMAN THYROID

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Abstract
Descriptions of the effect of thiouracil or thiourea upon the histology of the human thyroid have until now been limited to cases of Graves's disease [Moore, Sweeney, Cope, Rawson & Means, 1944; Shirer & Cohen, 1945; Halpert, Cavanaugh & Keltz, 1946]. In the course of a study of thiouracil therapy in heart failure the opportunity was taken to study in humans the histological stimulation first observed by MacKenzie & MacKenzie [1943] and Astwood, Sullivan, Bissell & Tyslowitz [1943] in the experimental animal, to find the degree of thyroid hyperplasia and colloid depletion evoked by increasing dosage with thiouracil, and to see at what stage of treatment changes are recognizable and how effectively the thyroid reverts to normal when the drug is stopped. This paper describes the changes in normal human thyroids and in one case the effect of additional thyrotrophic extract was studied. By 'normal', no more is implied than

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