Relationships of chromosomal and pathological findings in rous sarcoma virus‐induced tumours in the mouse

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Abstract
Sarcomas were induced in CBA mice by RSV‐SR inoculated in the neonatal period. The latent period ranged from 21 days up to more than 2 years; the peak incidence occurred around 4–5 months. The tumour incidence was about 45% after 6 months and nearly double after two years of observation. Multiple tumours, usually with closely similar latent periods, were frequent. Among the sarcomas studied chromosomally, small size, slow growth and a high degree of histological maturity were interconnected factors correlated with the occurrence of a normal diploid stemline. Opposite characteristics were typical of the sarcomas with a numerically and structurally changed stemline, especially the tetraploid group.Metastases were found only in the lungs and they occurred in approximately one‐third of the cases. No cysts were observed in the lymph nodes but a few instances are on record with cysts in the spleen and in the neighbourhood of the pancreas, as well as in connection with the sarcomas. A large amount of acid mucopolysaccharides could be found in all tumours studied in this respect.By back‐transfer to chickens, Rous sarcomas were elicited by roughly 75% of the mouse sarcomas investigated. Nearly all the negative mouse tumours had a latent period of more than one year.