Constriction of Human Umbilical Vein Under Aerobic and Anaerobic Conditions
- 1 January 1972
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 50 (1) , 1-5
- https://doi.org/10.1139/y72-001
Abstract
In the presence of metabolic inhibitors, the responses to serotonin of helically cut strips of human umbilical vein in Krebs–Henseleit solution at 37 °C were recorded isotonically. The tissues contracted to serotonin in a 95% nitrogen – 5% carbon dioxide atmosphere and in the presence of sodium cyanide (NaCN, 10−3M) and 2,4-dinitrophenol (DNP, 10−3M). The results indicate that human umbilical vein is capable of responding quite well to serotonin at very low oxygen levels and in the presence of sodium cyanide. The average maximum contractions to serotonin in the presence of NaCN and in the 95% nitrogen – 5% carbon dioxide atmosphere were, respectively, 91% and 88% of control. The contractile responses to serotonin were quite inhibited in the presence of 2,4-dinitrophenol. The combination of NaCN plus DNP did not inhibit the contractions to serotonin over that inhibited by DNP alone.Keywords
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