IMMUNOPHARMACOLOGIC PROPERTIES OF WY-16,922, A NEW ORALLY EFFECTIVE ANTIALLERGIC AGENT

  • 1 January 1976
    • journal article
    • research article
    • Vol. 197  (1) , 153-162
Abstract
In a series of tests designed to illustrate immune reactions similar to those obtained in atopic disease, Wy-16,922 [2''-carbamoyl-3''-methoxyoxanilic acid ethyl ester] effectively inhibited reaginic-mediated immunologic reactions in the skin, lungs and mast cell of rats. It was devoid of immunosuppressant antimediator, anti-inflammatory, steroid or bronchodilator properties and acute toxicity. Although the mechanism of action of Wy-16,922 is unknown, it appears to limit the release (not the effects) of allergic mediators in a manner similar to that described for disodium cromoglycate.

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