UNIQUE FEATURES OF HEAT-STABLE ENTEROTOXIN OF SHIGELLA-FLEXNERI

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (3) , 219-227
Abstract
Sephadex G-100 fractions of ultrasonic lysate of S. flexneri were compared to the fractions of Escherichia coli lysates of Ent-, LT+ST+, LT+ and ST+ strains. The range of MW of S. flexneri ST fractions was the same as that of E. coli LT [heat-labile] fractions. Rapid PF [permeability factor] activity was associated with the ST [heat-stable] peak in S. flexneri and followed the LT activity in the E. coli (LT+ST+) fractions, and appeared in the same MW range in the Ent- E. coli lysate. Cross neutralization could be demonstrated between S. flexneri ST and E. coli LT. Antigenic relationship between Shigella ST and choleragen seemed to be less expressed and rather unilateral.