Influence of splenectomy and the functional hyposplenism of coeliac disease on platelet count and volume

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Abstract
Platelet count and volume were measured in 84 splenectomized subjects, 142 patients with celiac disease and 77 healthy subjects. An inverse, non-linear correlation between platelet count and volume was found in healthy subjects and celiac patients, but was not present in splenectomized subjects who had higher platelet counts (P = 0.0001) and mean platelet volumes (P = 0.0001) than healthy subjects. Platelet counts correlated with splenic function in patients with celiac disease and were higher in patients with severe hyposplenism than in normosplenic celiacs (P = 0.0001). Splenic function did not influence the mean platelet volume (MPV) in celiac disease but normosplenic celiacs had higher MPV than normal subjects (P = 0.05). Serum Fe and red cell folate were not correlated to MPV in celiac disease. Splenic function effects platelet count and volume in non-celiac subjects and platelet count in celiac disease. Other unidentified factor(s) influence the MPV in celiac disease.