RENAL ALLOGRAFT REJECTION IN CD4+ T CELL-RECONSTITUTED ATHYMIC NUDE RATS
- 1 December 1990
- journal article
- immunobiology
- Published by Wolters Kluwer Health in Transplantation
- Vol. 50 (6) , 996-1000
- https://doi.org/10.1097/00007890-199012000-00020
Abstract
PVG-rnu/rnu nude rats reject a fully allogeneic DA renal allograft after the adoptive transfer of naive CD4+ T cells alone, but rejection is accompanied by the accumulation of many CD8+ leukocytes within the graft. In order to clearly establish the provenance of these CD8+ cells infiltrating rejecting kidney allografts, nude recipients (PVG-RT7a) were injected with CD4+ T cells from the PVG-RT7b congenic strain bearing an allotypic variant of the leukocyte-common antigen. Dual fluorescence and immunohistochemistry demonstrated that approximately 75% of the total infiltrate was host-derived; the donor-derived RT7b population was almost entirely (92–99%) CD4+, CD5+, CD3+, and αβTCR+. At least 97% of the CD8+ cells were of nude origin. There was noKeywords
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