Prophylaxis for postoperative deep-vein thrombosis. Synergistic effect of heparin and dihydroergotamine
- 5 January 1979
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 241 (1) , 39-42
- https://doi.org/10.1001/jama.241.1.39
Abstract
Randomized clinical trials in 300 patients undergoing major abdominal surgery or hip replacement arthroplasty were performed to investigate the efficacy of dihydroergotamine mesylate, heparin calcium or a combination of dihydroergotamine with heparin in preventing postoperative deep-vein thrombosis (DVT). The diagnosis of DVT was established by an uptake test using fibrinogen labeled with 125I. In patients undergoing hip replacement, phlebography was also employed to confirm or refute the presence of isotopic thrombi. The combination of dihydroergotamine and heparin is probably more effective than heparin or dihydroergotamine alone in preventing DVT.This publication has 1 reference indexed in Scilit:
- The Relationship of Platelet Coagulant Activities to Venous Thrombosis following Hip SurgeryBritish Journal of Haematology, 1976