Primary non‐Hodgkin's lymphoma of the intestine: a morphological, immunohistochemical and clinical study of 31 Chinese cases

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Abstract
Thirty‐one cases of primary non‐Hodgkin's lymphoma of the intestine were investigated. Twenty‐one were of B‐cell and 10 of T‐cell origin. The B‐cell lymphomas comprised two cases of low‐grade B‐cell lymphoma of mucosaassociated lymphoid tissue (MALT), one of centroblastic/centrocytic type, three of high‐grade B‐cell lymphoma coexisting with a low‐grade B‐cell lymphoma of MALT, nine of centroblastic, three of immunoblastic and three of Burkitt type. Of the T‐cell lymphomas, eight were of pleomorphic medium‐to large‐sized cell type and two of large cell anaplastic type. All the B‐cell lymphomas expressed CD20 (L26) and/or Ki‐B5; in six there was monotypic immunoglobulin light chain restriction. Membrane positivity for CD45RO (UCHL1) was observed in the 10 cases of T‐cell lymphoma, but the tumour cells did not express monocyte‐macrophage markers. Clinically, the patients with T‐cell lymphomas were usually young males with constitutional symptoms and their prognosis was significantly worse than those of patients with intestinal B‐cell lymphoma.