Time Course of Response of Thyroid Gland to Intravenous Injection of Thyrotrophic Hormone

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Abstract
The discharge of organically bound I131 from the thyroid gland of the rabbit, as measured by external neck counting, was used to study the time course of response to intravenous injections of thyrotropic hormone. Following the intravenous injection of either purified beef thyroid stimulating hormone (TSH) or a crude alkaline extract of rabbit anterior pituitary gland there was usually a distinct latent period of between 1/2 and 2 hours preceding the onset of discharge of I131. The rate of discharge fell off rapidly to approach control levels in less than 5 hours in 13 of 15 experiments. There are no qualitative differences between the effects of beef or rabbit TSH, indicating that these responses are not species specific.