AN INCREASE IN THE HALF-LIFE OF PENTOBARBITONE WITH THE ADMINISTRATION OF HALOTHANE IN SHEEP
Open Access
- 1 June 1973
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 45 (6) , 586-588
- https://doi.org/10.1093/bja/45.6.586
Abstract
The effect of halothane on the half-life of pentobarbitone was studied in sheep. Pento-barbitone was given in a dose of 20 mg/kg and halothane was administered via a mask for periods from 30 min up to 2 hr. Concentrations of pentobarbitone in whole Hood were measured and the half-life determined. In cross-over tests giving pentobarbitone alone, and pentobarbitone and halothane to eight sheep, increases in the half-life with halothane ranging from 4 to 323% (mean 71%) were observed.Keywords
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