Chromosome Mutations and pH Disturbances
- 1 April 1975
- journal article
- research article
- Published by Taylor & Francis in Archives of environmental health
- Vol. 30 (4) , 196-200
- https://doi.org/10.1080/00039896.1975.10666675
Abstract
Chromosomal anomalies, namely hypodiploidies, hyperdiploidies, and endoreduplications, developed in nearly 25% of metaphase plates of replicating human lymphocytes exposed in vitro to either acid (6.5 to 6.9) or alkaline (8.4 to 8.8) pH equilibriums. The G group was most susceptible to aneuploid formation. Mammalian mutations may develop as the result of a pH disturbance during cleavage of the fertilized zygote.Keywords
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