INFLUENCE OF VARIOUS PURIFIED INTERFERONS ON EFFECTS OF DRUGS IN MICE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 39  (1) , 113-125
Abstract
Direct determinations indicate that some types of interferon increase the duration of hexobarbital-induced sleep time and decrease acetaminophen toxicity. Pretreatment of mice with cloned human leukocyte interferon subtype A, IFN-.alpha.A, did not increase hexobarbital sleep time but pretreatment with mouse interferon or a hybrid human leukocyte interferon, IFN-.alpha.AD (Bgl), increased the duration of the effect of the barbiturate. Hybrid IFN-.alpha.AD (Bgl) also decreased the lethality of acetaminophen. These findings are predictable based on reports of hepatic cytochrome P450 depression resulting from treatment with some interferons.