Abstract
A serological study by complement fixation, of 37 cases of tsutsugamushi disease occurring in. Burma and the Philippine Is. revealed a variety of antigenic responses to the 3 strains of tsutsugamushi used in the tests, namely the Gilliam, Karp, and Seerengayee strains. Certain cases were predominantly of the Gilliam type, others of the Karp or Seer-angayee type, and the serums of a number of cases responded equally well to all 3 types. Cross fixation occurred in practically all cases. The results obtained as a whole do not indicate any clear differentiation of serological types. The Karp and Gilliam strains appear sufficiently distinctive, however, to warrant the use of these 2 in the testing of serums from cases of suspected tsutsugamushi illness. Weil-Felix titers with OXK antigen were much lower than complements-fixing titers with rickettsial antigens and persisted for a shorter time.

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