Cat-Scratch Skin Test Antigen: Purification by Heating

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Abstract
Since the first use of a skin test for cat-scratch disease by Harry Rose, M.D., on Frankline Hanger, M.D., in 1946,1 there have been no reports of transmission of hepatitis or other disease through the use of hundreds of tests with the antigen on thousands of people. Use of the antigen has prevented countless surgical procedures, especially biopsy or removal of lymph nodes, and it has also helped relieve the anxiety of patients and parents of patients faced with an unexplained lymphadenopathy. Nevertheless, potential danger from the test has prevented its use in some locations, including important medical centers, and has caused some physicians to worry about safety.

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