Classification and biological distribution of histamine receptor sub-types
- 1 October 1975
- journal article
- review article
- Published by Springer Nature in Inflammation Research
- Vol. 5 (4) , 277-295
- https://doi.org/10.1007/bf02205232
Abstract
The distribution and classification of histamine receptors in mammalian and avian tissues have been summarized in Tables 1–4. It is evident that histamine receptors are present on a number of morphologically distinct cell types and the proportion of cells bearing H1- and H2-receptors varies not only with the species but also with the cell source. The pharmacological receptors mediating mepyramine-sensitive histamine responses have been defined as H1-receptors. Receptors mediating mepyramine-resistant, but burimamide or metiamide-sensitive histamine responses have been classified as H2-receptors. Histamine responses mediated via H2-receptors seem to involve the adenylcyclase system resulting in elevation of intracellular cyclic-AMP level, which is susceptible to burimamide blockade but insensitive to β-adrenergic blocking agents. This mode of action of histamine involving H2-receptors and the adenyl cyclase system has been shown to stimulate the mammalian heart; promote gastric acid secretion; inhibit antigen-induced histamine release from leucocytes and inhibit lymphocyte-mediated cytotoxicity. It can further be concluded that both H1- and H2-receptors are widely distributed throughout the animal body in the gastro-intestinal, reproductive, respiratory and cardiovascular systems, nervous system and on mast cells and blood leucocytes. In these tissues, histamine receptors play an important role in physiological, immunological and immunopathological processes. Interaction of histamine with both H1- and H2-receptors in varying proportions modulates the overall manifestation of cardiovascular and respiratory syndromes during certain immunopathological conditions (e.g. inflammation, allergy and anaphylaxis). Histamine receptors also appear to play an important role in the development of immuno-competence and immunity.This publication has 158 references indexed in Scilit:
- Effect of burimamide and metiamide on pentagastrin-stimulated gastric acid secretion and gastric mucosal blood flow in catsCellular and Molecular Life Sciences, 1974
- Histamine H2 receptors and cyclic AMP in brainLife Sciences, 1974
- The role of histamine receptors in the stimulation of gastric acid secretionDigestive Diseases and Sciences, 1974
- Cardiovascular effects of burimamide and metiamideInflammation Research, 1974
- Differentiation of H10and H2-receptors mediating positive chronoand inotropic responses to histamine on atrial preparations of the guinea-pigInflammation Research, 1974
- Effects of burimamide, an antagonist of H-2 histamine receptors, in the gastric fistula dogDigestive Diseases and Sciences, 1974
- Effect of metiamide, a histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin, and peptone meal in manDigestive Diseases and Sciences, 1974
- Stimulation of acid and pepsin secretion in the fistula dog by 4(5)-methyl histamine, a specific H-2 agonistDigestive Diseases and Sciences, 1974
- The beta adrenergic theory of the atopic abnormality in bronchial asthmaJournal of Allergy, 1968
- The Anti-Anaphylactic Activity of Ethanolamine and CholineJournal of Pharmacy and Pharmacology, 1961