Characteristics of post‐transcriptional gene silencing
Open Access
- 1 November 2001
- journal article
- review article
- Published by Springer Nature in EMBO Reports
- Vol. 2 (11) , 992-996
- https://doi.org/10.1093/embo-reports/kve231
Abstract
A number of gene silencing phenomena that inactivate genes at the post‐transcriptional level have been identified. Due to its potential for studying gene function, post‐transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and discuss the possible biological roles of these artificially induced phenomena. We also discuss other features of PTGS such as the mechanism of mRNA degradation, the nature of the silencing signal and the mechanism of PTGS inhibition by viral proteins.Keywords
This publication has 55 references indexed in Scilit:
- A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegansScience, 2001
- A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of thelet-7Small Temporal RNAScience, 2001
- Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental TimingCell, 2001
- HC-Pro Suppression of Transgene Silencing Eliminates the Small RNAs but Not Transgene Methylation or the Mobile SignalPlant Cell, 2001
- RNAiCell, 2000
- Stochastic and Nonstochastic Post-Transcriptional Silencing of Chitinase and β-1,3-Glucanase Genes Involves Increased RNA Turnover—Possible Role for Ribosome-Independent RNA DegradationPlant Cell, 1999
- Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plantsCurrent Opinion in Biotechnology, 1996
- Post-transcriptional cosuppression of beta-1,3-glucanase genes does not affect accumulation of transgene nuclear mRNA.Plant Cell, 1995
- Post-Transcriptional Cosuppression of b-1,3-Glucanase Genes Does Not Affect Accumulation of Transgene Nuclear mRNAPlant Cell, 1995
- Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in transPlant Cell, 1990