The Influence of Narcotics on Anaphylactic Shock

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Abstract
Summary: The findings of Besredka concerning the anti-anaphylactic action of certain narcotics were confirmed. In the control experiments only 4 out of 25 guinea pigs survived the shocking reinjection. Urethane administered to sensitized guinea pigs prior to the shocking reinjection led to the survival of 15 out of 30 animals. Although ether inhalation led to the survival of three out of nine animals it is felt that these experiments are not conclusive. Morphine hydrochloride does not protect guinea pigs from fatal anaphylactic shock. Besredka's interpretation of this phenomenon, which assumes that the action of the narcotics takes place in the central nervous system, is held to be incorrect. An explanation is advanced on the basis of their action on the bronchial musculature.

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